Understanding how cholinergic systems affect movement and attention in Parkinson's disease
Cholinergic mechanisms of attentional-motor integration and gait dysfunction in Parkinson Disease
This study is looking at how certain brain systems that help with attention and movement are affected in people with Parkinson's disease, to better understand why some walking and thinking problems don't get better with usual treatments, and it hopes to find new ways to help improve these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10931687 on NIH RePORTER |
What this research studies
This research investigates the role of cholinergic systems in the integration of attention and motor functions in patients with Parkinson's disease. It aims to understand how degeneration of these systems contributes to gait and cognitive impairments that are resistant to standard dopamine replacement therapies. By using advanced imaging techniques and animal models, the study will explore specific patterns of cholinergic degeneration and their relationship to movement difficulties and cognitive decline. The findings could lead to new therapeutic strategies to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience gait and cognitive difficulties.
Not a fit: Patients with Parkinson's disease who do not exhibit gait or cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gait and cognitive issues in Parkinson's disease patients.
How similar studies have performed: Previous research has shown promising results in understanding cholinergic mechanisms in Parkinson's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Albin, Roger L — University of Michigan at Ann Arbor
- Study coordinator: Albin, Roger L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.