Understanding how choline transport affects health and metabolic diseases
Official title: The physiological and molecular function of choline transport in health and metabolic disease
Funded at Rockefeller University · NIH-10944563 · Data updated 2026-11-12
This study is looking at how our bodies take in choline, an important nutrient, and how this process might affect our health, especially for people dealing with metabolic diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $746,070 |
| NIH project number | 1R01DK140337-01 |
| Project ID | NIH-10944563 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have metabolic disorders or conditions related to nutrient absorption.
✕Less likely to help
Patients who are under 21 years old or do not have any metabolic diseases may not receive direct benefits from this research.
What this research studies
This research investigates the role of choline transport in maintaining nutrient balance within cells and its implications for health and metabolic diseases. By identifying the high-affinity choline transporter that is present in various tissues, the study aims to uncover how choline, an essential nutrient, is absorbed by cells. The approach includes genome-wide association studies to link genetic variations with choline transport mechanisms, potentially using advanced techniques like CRISPR for functional analysis. Patients may benefit from insights into how choline transport affects their health and metabolic conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing metabolic diseases by improving our understanding of choline transport.
How similar studies have gone: Previous research has shown success in understanding nutrient transport mechanisms, but this specific focus on choline transport is relatively novel.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Birsoy, Kivanc — Rockefeller University
- Study coordinator: Birsoy, Kivanc
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.