Understanding how choline transport affects health and metabolic diseases
The physiological and molecular function of choline transport in health and metabolic disease
This study is looking at how our bodies take in choline, an important nutrient, and how this process might affect our health, especially for people dealing with metabolic diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10944563 on NIH RePORTER |
What this research studies
This research investigates the role of choline transport in maintaining nutrient balance within cells and its implications for health and metabolic diseases. By identifying the high-affinity choline transporter that is present in various tissues, the study aims to uncover how choline, an essential nutrient, is absorbed by cells. The approach includes genome-wide association studies to link genetic variations with choline transport mechanisms, potentially using advanced techniques like CRISPR for functional analysis. Patients may benefit from insights into how choline transport affects their health and metabolic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may have metabolic disorders or conditions related to nutrient absorption.
Not a fit: Patients who are under 21 years old or do not have any metabolic diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing metabolic diseases by improving our understanding of choline transport.
How similar studies have performed: Previous research has shown success in understanding nutrient transport mechanisms, but this specific focus on choline transport is relatively novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Birsoy, Kivanc — Rockefeller University
- Study coordinator: Birsoy, Kivanc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.