Understanding how cholesterol pathways help optic nerve regeneration
Regulation of successful optic nerve regeneration by the mevalonate/cholesterol pathway
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11063128
This study is looking at how certain substances in the body, like cholesterol, help the optic nerve heal and regain vision, using zebrafish as a model, with the hope that what we learn can lead to new treatments for people with optic nerve injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11063128 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind optic nerve regeneration, particularly focusing on the role of cholesterol and the mevalonate pathway. Using zebrafish, which can regenerate their optic nerves and recover vision, the study aims to identify key factors that promote this regeneration. By analyzing retinal ganglion cells during the regeneration process, researchers hope to uncover how certain proteins, like srebf2, influence the regeneration of damaged optic nerves. The ultimate goal is to translate these findings into potential treatments for patients suffering from optic nerve injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing vision loss due to optic neuropathies, such as glaucoma.
Not a fit: Patients with optic nerve damage from non-regenerative causes or those who do not have optic neuropathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore vision in patients with optic nerve damage.
How similar studies have performed: Other research has shown promise in understanding optic nerve regeneration, but this specific approach using zebrafish and cholesterol pathways is relatively novel.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VELDMAN, MATTHEW B — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: VELDMAN, MATTHEW B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: axon injury, axonal injury