Understanding how cholesterol moves within cells and its role in Alzheimer's disease
Investigating intracellular cholesterol distribution and trafficking using novel environment-sensitive cholesterol probes
This study is looking at how cholesterol moves around inside cells and how that might be connected to Alzheimer's disease, using special tools to see this in real-time, which could help us find new ways to treat the condition.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project ID | NIH-10522716 on NIH RePORTER |
What this research studies
This research investigates the distribution and movement of cholesterol inside cells, particularly how it relates to Alzheimer's disease. By developing new fluorescent probes that can track cholesterol in live cells, the study aims to uncover how cholesterol trafficking affects the progression of Alzheimer's. The approach combines advanced imaging techniques and computational methods to provide insights into the cellular mechanisms involved in neurodegeneration. Patients may benefit from a better understanding of how cholesterol impacts Alzheimer's, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to cholesterol metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target cholesterol management in Alzheimer's disease.
How similar studies have performed: Previous research has shown that targeting cholesterol metabolism can have positive effects in neurodegenerative diseases, suggesting this approach may yield valuable insights.
Where this research is happening
Boca Raton, United States
- Florida Atlantic University — Boca Raton, United States (Active)
Researchers
- Principal investigator: Stawikowski, Maciej J. — Florida Atlantic University
- Study coordinator: Stawikowski, Maciej J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.