Understanding how cholesterol moves within cells
Mechanisms of nonvesicular cholesterol transport
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11138702
This study is looking at how certain proteins help move cholesterol inside our cells, which is important for keeping our hearts healthy, and it hopes to find new ways to help people manage cholesterol and reduce the risk of heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11138702 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular pathways that regulate cholesterol transport within cells, focusing on the role of specific proteins known as Asters. These proteins are crucial for moving cholesterol from the plasma membrane to the endoplasmic reticulum, which is essential for maintaining cellular health. By identifying additional factors involved in this process, the research aims to uncover new therapeutic targets for treating cardiovascular diseases. Patients may benefit from insights gained about cholesterol management and its implications for heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases or conditions related to cholesterol metabolism.
Not a fit: Patients who do not have cardiovascular issues or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiovascular diseases by improving our understanding of cholesterol transport mechanisms.
How similar studies have performed: Previous research has shown promise in understanding lipid transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TONTONOZ, PETER J — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: TONTONOZ, PETER J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiovascular Diseases, cardiovascular disorder