Understanding how cholesterol affects immune cells in children's skin.
Parsing cholesterol metabolite regulation of skin immunocytes in children to identify archetypes of human neonatal immune system
['FUNDING_U01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11036369
This study is looking at how certain substances from cholesterol affect immune cells in the skin of children, especially a type of cell that helps fight off illnesses, to better understand how diet and early life experiences shape their immune system and overall health.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11036369 on ClinicalTrials.gov |
What this research studies
This research investigates how cholesterol metabolites influence immune cells in the skin of children, particularly focusing on a type of lymphocyte that plays a crucial role in immune responses. By examining how these cells develop and function in early life, the study aims to uncover the relationship between diet, immune system development, and potential metabolic disorders. The research involves analyzing immune responses in skin samples and understanding the signaling pathways involved in these processes. This could provide insights into how early life factors affect long-term health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11, particularly those with a focus on early life immune development.
Not a fit: Patients who are adults or those with established immune disorders unrelated to early life development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of immune-related conditions in children.
How similar studies have performed: Previous research has shown promising results in understanding immune responses related to diet and early life development, suggesting that this approach could yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANG, JOONSOO — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: KANG, JOONSOO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.