Understanding how cholesterol affects fat cells
A novel role of cholesterol and SR-BI in adipocyte biology
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10918250
This study is looking at how cholesterol from good sources affects fat cells in our bodies and whether our genes play a role in this process, which could help us understand obesity and related health issues better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10918250 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cholesterol and a specific receptor (SR-BI) in fat cells, which are crucial for energy storage in the body. The study aims to uncover how cholesterol from HDL influences fat accumulation in these cells and whether genetic factors affect this process in humans. By using advanced techniques like ATAC sequencing and mouse models, researchers will explore the mechanisms behind cholesterol regulation in fat cells. This could lead to insights into obesity and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity or metabolic disorders who may have genetic factors influencing cholesterol and fat cell function.
Not a fit: Patients who do not have obesity or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity and metabolic diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of cholesterol in fat metabolism, but this specific approach is novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MINEO, CHIEKO — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: MINEO, CHIEKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.