Understanding how cholera bacteria interact with the body
Host-pathogen interactions in experimental cholera
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11078700
This research explores how the bacteria that cause cholera interact with the human body to better understand this severe diarrheal disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11078700 on ClinicalTrials.gov |
What this research studies
Cholera is a serious illness causing severe dehydration and diarrhea, and this project aims to uncover fundamental ways the cholera bacteria, called Vibrio cholerae, colonize the small intestine and cause epidemics. We are looking into how different types of cholera bacteria, specifically Ogawa and Inaba serotypes, behave differently within the body and how these differences affect their ability to cause disease. We are also exploring how cholera toxin, which causes fluid secretion, changes the body's response at a cellular level. By understanding these interactions, we hope to find new ways to combat cholera.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals at risk of or suffering from cholera in the future.
Not a fit: Patients not affected by cholera would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing and treating cholera by targeting the specific ways the bacteria cause illness.
How similar studies have performed: This research builds upon decades of prior work and tools developed by the researchers, suggesting a foundation of established methods in this field.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALDOR, MATTHEW K — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: WALDOR, MATTHEW K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.