Understanding how cholera bacteria evolve in aquatic environments
Official title: Biotype-specific evolution
Funded at Wayne State University · NIH-10761802 · Data updated 2026-11-12
This study looks at how two types of cholera bacteria behave in water by using zebrafish, helping us understand why one type has mostly vanished and the other continues to thrive, which could help us prevent future cholera outbreaks.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | January 6, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $188,180 |
| NIH project number | 5R21AI171072-02 |
| Project ID | NIH-10761802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in or originating from developing countries where cholera is prevalent.
✕Less likely to help
Patients who do not reside in cholera-affected regions or those who have no history of cholera exposure may not benefit from this research.
What this research studies
This research investigates the evolution of cholera bacteria, specifically focusing on the differences between two biotypes: classical and El Tor. Using a zebrafish model, the study aims to explore how these bacteria interact with fish in their natural habitats, which may reveal why the classical biotype has largely disappeared. By examining the genetic factors that allow El Tor to thrive, the research seeks to uncover the mechanisms behind its prolonged colonization in aquatic environments. This could provide insights into cholera outbreaks and inform public health strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cholera outbreaks, potentially saving lives in affected regions.
How similar studies have gone: Previous research has shown success in using animal models to study bacterial colonization and evolution, indicating that this approach may yield valuable insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Withey, Jeffrey H — Wayne State University
- Study coordinator: Withey, Jeffrey H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.