Understanding how cholera bacteria cause severe illness
The Role of Type VI Secretion in Cholera Pathogenesis
This study is looking at how certain types of cholera bacteria use a special system to outcompete others in the gut, which helps us understand why cholera can be so severe, and the findings could help improve ways to prevent and treat cholera outbreaks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10690425 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which specific strains of Vibrio cholerae lead to cholera outbreaks, focusing on the type VI secretion system (T6SS) that these bacteria use to compete with other strains in the small intestine. By examining how toxigenic strains utilize T6SS to deliver toxic proteins to neighboring bacteria, the study aims to uncover the genetic and environmental factors that contribute to cholera's virulence. The research employs advanced genetic and microbiological techniques to analyze bacterial interactions and their impact on disease severity. Insights gained could inform strategies for preventing and treating cholera outbreaks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in regions prone to cholera outbreaks, particularly those with a history of cholera infection or exposure.
Not a fit: Patients who are not at risk of cholera infection, such as those living in areas with robust sanitation and healthcare systems, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cholera, potentially saving thousands of lives each year.
How similar studies have performed: Other research has shown success in understanding bacterial competition mechanisms, suggesting that this approach could yield valuable insights into cholera pathogenesis.
Where this research is happening
New York, United States
- City College of New York — New York, United States (Active)
Researchers
- Principal investigator: Pukatzki, Stefan — City College of New York
- Study coordinator: Pukatzki, Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.