Understanding how cholera bacteria break free from biofilms
This way out: Spatiotemporal regulation of Vibrio cholerae biofilm dispersal
['FUNDING_OTHER'] · CARNEGIE-MELLON UNIVERSITY · NIH-10872244
This study is looking at how cholera bacteria move from sticky groups to swimming freely, which helps them spread, and the findings could help us find better ways to prevent cholera for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CARNEGIE-MELLON UNIVERSITY (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10872244 on ClinicalTrials.gov |
What this research studies
This research investigates the lifecycle of Vibrio cholerae, focusing on how these bacteria transition from biofilms to free-swimming forms. By using advanced microscopy techniques, the study aims to identify the molecular signals and mechanisms that control biofilm dispersal, which is crucial for the spread of cholera. The research involves high-content genetic screening to pinpoint specific proteins and enzymes that facilitate this process. Patients may benefit from insights gained into how cholera spreads, potentially leading to improved prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in areas prone to cholera outbreaks or those with a history of cholera infection.
Not a fit: Patients who are not affected by cholera or live in regions where cholera is not a concern may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for preventing cholera outbreaks by understanding how the bacteria disperse.
How similar studies have performed: Other research has shown success in understanding bacterial biofilm dynamics, but the specific mechanisms of Vibrio cholerae dispersal are less well-explored, making this a novel investigation.
Where this research is happening
PITTSBURGH, UNITED STATES
- CARNEGIE-MELLON UNIVERSITY — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRIDGES, ANDREW A. — CARNEGIE-MELLON UNIVERSITY
- Study coordinator: BRIDGES, ANDREW A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.