Understanding how cholera bacteria attach and cause infection
Official title: Regulation of the Vibrio cholerae MSHA Pilus Drives Host Colonization and Pathogenesis
Funded at Illinois State University · NIH-10974534 · Data updated 2026-11-12
This study is looking at how the bacteria that cause cholera stick to surfaces and form protective layers, focusing on a special structure they use to do this, which could help us find new ways to prevent cholera infections.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Illinois State University NIH-funded |
| Lab location | 1 site (Normal, United States) |
| Project start | July 2, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $432,741 |
| NIH project number | 1R15AI185921-01 |
| Project ID | NIH-10974534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals living in areas prone to cholera outbreaks or those at high risk of infection.
✕Less likely to help
Patients who are not at risk of cholera infection or who live in regions where cholera is not prevalent may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the cholera-causing bacteria, Vibrio cholerae, attach to surfaces and form biofilms, which are crucial for their survival and ability to infect hosts. The study focuses on a specific structure called the MSHA pilus, which plays a key role in this attachment process. By examining the genetic components that regulate the production of MSHA pili, the research aims to uncover how these bacteria transition from their environment to infecting a host. This could lead to new insights into preventing cholera infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cholera infections, potentially saving lives.
How similar studies have gone: Previous research has shown success in understanding bacterial attachment mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Illinois State University
Normal, United States Active
Researchers
- Principal investigator: Floyd, Kyle a — Illinois State University
- Study coordinator: Floyd, Kyle a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.