Understanding how cholera bacteria and their viruses evolve together
Molecular mechanisms driving the coevolution of clinical isolates of phages and epidemic Vibrio cholerae
This study looks at how cholera bacteria fight off viruses that try to attack them, and by understanding these changes, we hope to find better ways to treat and prevent cholera for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11134210 on NIH RePORTER |
What this research studies
This research investigates the ongoing evolutionary battle between cholera-causing bacteria, Vibrio cholerae, and their viral predators, known as phages. By analyzing clinical samples collected over time, the study aims to uncover the genetic changes that allow these bacteria to survive against phage attacks. Patients may benefit from insights gained into how cholera strains adapt, potentially leading to improved treatments and prevention strategies. The research employs advanced genomic techniques to track these changes and understand the dynamics of this microbial arms race.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals living in regions affected by cholera outbreaks, particularly in areas like Bangladesh.
Not a fit: Patients who do not reside in cholera-endemic regions or those not affected by antibiotic-resistant bacterial infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for preventing and treating cholera infections.
How similar studies have performed: Previous research has shown success in understanding bacterial evolution and resistance mechanisms, indicating that this approach has potential for impactful findings.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Seed, Kimberley Diane — University of California Berkeley
- Study coordinator: Seed, Kimberley Diane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.