Understanding how cholera bacteria adapt to cause disease
Official title: Rewiring networks for a pathogenic lifestyle
Funded at University of Rochester · NIH-10893669 · Data updated 2026-11-12
This study is looking at how certain types of cholera bacteria change to cause illness, which could help us find better ways to prevent and treat cholera for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $609,924 |
| NIH project number | 1R56AI170638-01A1 |
| Project ID | NIH-10893669 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in or traveling to regions where cholera is endemic, particularly in Asia and Africa.
✕Less likely to help
Patients who do not reside in cholera-endemic areas or who are not at risk of cholera infection may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Vibrio cholerae, the bacteria responsible for cholera, adapts to become pathogenic. It focuses on non-O1/non-O139 serogroup strains that are increasingly causing sporadic cases of cholera worldwide. By utilizing genomic sequencing and studying specific genetic elements, the research aims to uncover how these bacteria regulate their virulence factors and contribute to disease. Patients may benefit from insights that could lead to improved prevention and treatment strategies for cholera.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of cholera, potentially reducing the incidence and severity of the disease.
How similar studies have gone: Other research has shown success in understanding bacterial virulence mechanisms, but this specific focus on non-O1/non-O139 strains is relatively novel.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Dziejman, Michelle — University of Rochester
- Study coordinator: Dziejman, Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.