Understanding how chloropicrin and phosgene affect lung health
Official title: Pulmonary Pathophysiologic Mechanisms of Chloropicrin and Phosgene
Funded at University of California at Davis · NIH-10907752 · Data updated 2026-11-12
This study is looking at how two harmful chemicals, chloropicrin and phosgene, can hurt your lungs and how your body tries to heal from that damage, using animals to learn more about what happens over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $483,000 |
| NIH project number | 5R01ES034419-02 |
| Project ID | NIH-10907752 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to chloropicrin or phosgene and are experiencing respiratory issues.
✕Less likely to help
Patients who have not been exposed to these chemical agents or do not have lung-related health issues may not benefit from this research.
What this research studies
This research investigates the harmful effects of chloropicrin and phosgene, two chemical agents that can cause acute lung injury. The study focuses on how these substances lead to lung damage and the body's response to this injury over time. By using animal models, researchers will explore the mechanisms of toxicity, including how immune cells react and how tissue repair processes are initiated. The goal is to better understand the long-term impacts of exposure to these chemicals on lung health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for lung injuries caused by chemical exposures.
How similar studies have gone: Previous research has shown that understanding the mechanisms of chemical-induced lung injury can lead to significant advancements in treatment strategies.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Van Winkle, Laura S — University of California at Davis
- Study coordinator: Van Winkle, Laura S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.