Understanding how chloride levels in neurons affect seizures in newborns
Timing of Neuronal Chloride Uptake for Control of Neonatal Seizure
This study is looking at how the levels of chloride in brain cells might affect seizures in newborns who have had a lack of oxygen, with the hope of finding new ways to help prevent or lessen those seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001165 on NIH RePORTER |
What this research studies
This research investigates the role of chloride concentration in neurons and its impact on seizures in newborns who have experienced hypoxia-ischemia. By examining how chloride ions enter neurons and affect GABA signaling, the study aims to identify therapeutic strategies that can prevent or reduce seizures. The researchers will use advanced imaging techniques and established animal models to explore the effects of manipulating chloride transporters on neuronal health and seizure activity. The ultimate goal is to find an optimal treatment window to protect newborns from recurrent seizures following brain injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns up to 4 weeks old who have suffered from hypoxia-ischemia and are at risk for seizures.
Not a fit: Patients who are older than 11 years or who have not experienced hypoxia-ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent seizures in newborns, improving their long-term neurological outcomes.
How similar studies have performed: Previous research has shown promise in targeting chloride transport mechanisms to manage seizures, suggesting that this approach may be effective.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dzhala, Volodymyr — Massachusetts General Hospital
- Study coordinator: Dzhala, Volodymyr
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.