Understanding how chloride levels affect health and disease
Fluorescent Biosensors to Illuminate Chloride Homeostasis and Signaling
This study is looking at how chloride levels in our bodies affect health and diseases like cystic fibrosis and cancer, using special tools to see and measure these levels in living cells, which could help us find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11015799 on NIH RePORTER |
What this research studies
This research investigates the role of chloride ions in various physiological functions and diseases. By developing advanced fluorescent biosensors, the project aims to visualize and measure chloride levels in living systems, providing insights into how disruptions in chloride homeostasis can lead to conditions like cystic fibrosis and cancer. The approach includes engineering new imaging technologies and applying them in user-friendly cell lines to facilitate widespread use in biological research. Ultimately, this work seeks to enhance our understanding of chloride's role in health and disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by conditions linked to chloride dysregulation, such as cystic fibrosis, certain cancers, and cardiac dysfunction.
Not a fit: Patients with conditions unrelated to chloride homeostasis or those not experiencing any chloride-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments targeting chloride imbalances, improving health outcomes for patients with related diseases.
How similar studies have performed: Other research has shown promise in using biosensors for monitoring ion levels, suggesting that this approach could yield valuable insights into chloride's role in health and disease.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Dodani, Sheel — University of Texas Dallas
- Study coordinator: Dodani, Sheel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.