Understanding how chloride levels affect brain cell function in Parkinson's disease
Chloride Homeostasis in Lysosomal Function and Parkinson's Disease
This study is looking at how chloride ions affect the tiny waste-cleaning parts of our cells, called lysosomes, and how problems with these ions might contribute to the nerve cell damage seen in Parkinson's disease, with the hope of finding new ways to help manage or treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10842451 on NIH RePORTER |
What this research studies
This research investigates the role of chloride ions in the function of lysosomes, which are essential for cellular waste management, particularly in the context of Parkinson's disease (PD). The study aims to uncover how disruptions in chloride homeostasis can lead to neuronal stress and degeneration. By examining the molecular mechanisms involved, the research seeks to identify potential therapeutic targets that could improve neuronal health and function in PD. Patients may benefit from insights gained about how to better manage or treat their condition based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk of developing neurodegenerative disorders.
Not a fit: Patients with non-neurological conditions or those without any neurodegenerative diseases may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or managing Parkinson's disease by targeting chloride homeostasis.
How similar studies have performed: While the specific focus on lysosomal chloride in Parkinson's disease is relatively novel, similar research has shown promise in understanding cellular mechanisms in other neurodegenerative diseases.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Mao, Zixu — Emory University
- Study coordinator: Mao, Zixu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.