Understanding how chloride channels and transporters work in the body
Official title: Structure and function of chloride channels, transporters and scramblases
Funded at Weill Medical Coll of Cornell Univ · NIH-11004353 · Data updated 2026-11-12
This study is looking at how certain proteins that help with salt balance and muscle function work, which could help us find new treatments for genetic conditions that affect bones, kidneys, brains, and muscles.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $511,043 |
| NIH project number | 5R35GM152012-02 |
| Project ID | NIH-11004353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inherited disorders affecting bone, kidney, brain, or muscle function due to mutations in chloride channels or transporters.
✕Less likely to help
Patients without genetic disorders related to chloride channels or transporters may not benefit from this research.
What this research studies
This research investigates the structure and function of chloride channels and transporters, which are essential for various physiological processes such as salt absorption, blood coagulation, and neuromuscular function. By examining how these proteins operate at the molecular level, the research aims to uncover the mechanisms that regulate their activity. This knowledge could lead to the development of new treatments for inherited disorders caused by mutations in these proteins, affecting bones, kidneys, brains, and muscles.
Why it matters
Potential benefit: If successful, this research could lead to new pharmacological treatments for patients with genetic disorders related to chloride channels and transporters.
How similar studies have gone: Previous research has shown promise in understanding similar membrane proteins, indicating potential for success in this area.
Where this research is happening
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Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Accardi, Alessio — Weill Medical Coll of Cornell Univ
- Study coordinator: Accardi, Alessio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.