Understanding how chloride channels and transporters work in the body
Structure and function of chloride channels, transporters and scramblases
This study is looking at how certain proteins that help with salt balance and muscle function work, which could help us find new treatments for genetic conditions that affect bones, kidneys, brains, and muscles.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004353 on NIH RePORTER |
What this research studies
This research investigates the structure and function of chloride channels and transporters, which are essential for various physiological processes such as salt absorption, blood coagulation, and neuromuscular function. By examining how these proteins operate at the molecular level, the research aims to uncover the mechanisms that regulate their activity. This knowledge could lead to the development of new treatments for inherited disorders caused by mutations in these proteins, affecting bones, kidneys, brains, and muscles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inherited disorders affecting bone, kidney, brain, or muscle function due to mutations in chloride channels or transporters.
Not a fit: Patients without genetic disorders related to chloride channels or transporters may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new pharmacological treatments for patients with genetic disorders related to chloride channels and transporters.
How similar studies have performed: Previous research has shown promise in understanding similar membrane proteins, indicating potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Accardi, Alessio — Weill Medical Coll of Cornell Univ
- Study coordinator: Accardi, Alessio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.