Understanding how Chlamydia trachomatis bacteria use a key nutrient
Functional relevance of C. trachomatis trp operon polymorphism
This research helps us understand how Chlamydia trachomatis, a common bacterial infection, controls its use of a vital nutrient called tryptophan.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11172446 on NIH RePORTER |
What this research studies
Chlamydia trachomatis is a bacterium that can cause infections, including blindness and sexually transmitted diseases. This project looks closely at how these bacteria manage their tryptophan, an important building block they need to survive. We believe that if Chlamydia trachomatis uses too much tryptophan, it might take away other important nutrients, affecting its ability to cause disease. By studying the genetic controls that regulate tryptophan use, we hope to uncover new ways to disrupt the bacteria's growth.
Who could benefit from this research
Good fit: This foundational research is relevant to anyone affected by Chlamydia trachomatis infections.
Not a fit: Patients not affected by Chlamydia trachomatis infections would not directly benefit from this specific research.
Why it matters
Potential benefit: Successfully understanding these bacterial processes could lead to new ways to treat or prevent Chlamydia trachomatis infections.
How similar studies have performed: While the specific "trans"-attenuation mechanism is a recent discovery, other studies have shown success in targeting bacterial metabolic pathways for treatment.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Carabeo, Rey a — University of Nebraska Medical Center
- Study coordinator: Carabeo, Rey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.