Understanding how Chlamydia hides inside human cells
Dissecting the role of the Inclusion membrane protein IncE, a master multi-tasking scaffolding protein, in the pathogenesis of Chlamydia trachomatis infections
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11114015
This research explores how the Chlamydia bacteria creates a special hiding place inside our cells to cause infections, aiming to find new ways to fight it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11114015 on ClinicalTrials.gov |
What this research studies
Chlamydia trachomatis infections are a major health concern, and currently, there is no vaccine to prevent them. This project focuses on a key protein called IncE, which Chlamydia uses to build a protective compartment, or 'inclusion,' inside human cells. By studying how IncE interacts with our own cell proteins, like SNX5/6 and STX7/12, we can learn how Chlamydia establishes its hidden home. Understanding these interactions could reveal new weaknesses in the bacteria's strategy, paving the way for better treatments or a vaccine.
Who could benefit from this research
Good fit: This foundational laboratory research does not involve direct patient participation, but future clinical applications would target individuals at risk for or suffering from Chlamydia trachomatis infections.
Not a fit: Patients without Chlamydia trachomatis infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new drugs or vaccines that prevent Chlamydia from establishing infections, ultimately reducing the burden of this common disease.
How similar studies have performed: This research builds on new discoveries about the IncE protein's interactions, suggesting a novel approach to understanding Chlamydia infection mechanisms.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ENGEL, JOANNE N. — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: ENGEL, JOANNE N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections