Understanding how Chlamydia bacteria change forms to spread infection
Mechanism of RB-to-EB Conversion in Chlamydia
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10774220
This study is looking at how Chlamydia bacteria change from a harmless form to an infectious one, focusing on how their size affects this process, which could help us find better ways to understand and control Chlamydia infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10774220 on ClinicalTrials.gov |
What this research studies
This research investigates the conversion process of Chlamydia bacteria from a non-infectious form (reticulate body) to an infectious form (elementary body). By examining the size of the bacteria and how it influences this conversion, the study aims to uncover new regulatory mechanisms that control this critical process. Using advanced imaging techniques, researchers will explore how changes in size affect the timing and efficiency of this conversion. This could lead to new insights into how Chlamydia infections spread and how they might be controlled.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chlamydia infections or those at high risk for such infections.
Not a fit: Patients who do not have Chlamydia infections or are not at risk for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating Chlamydia infections.
How similar studies have performed: While the specific approach of examining size regulation in Chlamydia is novel, similar studies have successfully identified mechanisms of bacterial infection and conversion in other pathogens.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUETTERLIN, CHRISTINE — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SUETTERLIN, CHRISTINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chlamydial Infection, chlamydial disease