Understanding how children's immune systems respond to sapovirus
Mucosal immunity to sapovirus in early childhood
['FUNDING_R21'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10786130
This study is looking at how young children’s bodies fight off sapovirus, a virus that can cause stomach bugs, by checking their saliva and stool for antibodies, which will help in creating better vaccines for kids under 2 years old.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10786130 on ClinicalTrials.gov |
What this research studies
This research investigates the immune response to sapovirus, a significant cause of gastroenteritis in young children. The study focuses on understanding how children's bodies produce antibodies against this virus, particularly in saliva and stool, which are crucial for developing effective vaccines. By examining the natural immunity in children under 24 months, the research aims to identify key immune responses that could inform future vaccine development. The approach includes collecting samples from children and analyzing their immune responses to sapovirus.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 24 months of age who may be at risk for sapovirus infections.
Not a fit: Patients who are older than 24 months or those who have already been vaccinated against sapovirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines against sapovirus, reducing the incidence of gastroenteritis in young children.
How similar studies have performed: While there has been significant research on other enteric viruses, this specific investigation into sapovirus immunity is relatively novel and untested.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BECKER-DREPS, SYLVIA IRENE — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: BECKER-DREPS, SYLVIA IRENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.