Understanding how children's immune systems respond to adenovirus infections in Bangladesh
Official title: Active and passive humoral immunity to enteric adenovirus infection in Bangladeshi children
Funded at University of Virginia · NIH-11033486 · Data updated 2026-11-12
This study is looking at how young children in Bangladesh fight off adenovirus infections, which can cause diarrhea, by checking both their own immune responses and the antibodies they get from their mothers' breast milk, to find better ways to help protect them from getting sick.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $192,260 |
| NIH project number | 1K23AI187708-01 |
| Project ID | NIH-11033486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Bangladeshi children under the age of 5 who are experiencing adenovirus infections.
✕Less likely to help
Patients outside of the age range of 0-5 years or those not affected by adenovirus infections may not benefit from this research.
What this research studies
This research investigates how the immune systems of young children in Bangladesh respond to adenovirus infections, which are a significant cause of diarrhea in low- and middle-income countries. The study will analyze both active immunity, generated by the children's own immune responses, and passive immunity, provided through breast milk antibodies from their mothers. By examining the antibody responses in both the children and their mothers, the research aims to identify effective ways to enhance immunity against these infections. The findings could lead to improved strategies for preventing and treating adenovirus-related illnesses in children.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for adenovirus infections in young children, potentially reducing the incidence of diarrhea and its associated complications.
How similar studies have gone: Previous research has shown promise in understanding immune responses to viral infections in children, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Hendrick, Jennifer Marie — University of Virginia
- Study coordinator: Hendrick, Jennifer Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.