Understanding how children's immune responses affect recovery from severe viral pneumonia
Official title: Multidimensional analysis of the regulatory T cell response in children with severe viral pneumonia
Funded at Lurie Children's Hospital of Chicago · NIH-10950120 · Data updated 2026-11-12
This study is looking into why young kids get really sick from viral pneumonia and how they can get better, focusing on how their immune system works, so we can find new ways to help them recover faster and avoid long-term breathing problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $163,080 |
| NIH project number | 1K08HL176208-01 |
| Project ID | NIH-10950120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under five years old who have been diagnosed with severe viral pneumonia.
✕Less likely to help
Patients who are adults or those with mild viral infections may not benefit from this research.
What this research studies
This research investigates why children are more susceptible to severe viral pneumonia and how they recover from it. By studying the immune responses, particularly the role of regulatory T cells, the research aims to uncover the mechanisms that lead to lung injury and prolonged inflammation in young patients. The team uses a mouse model that mimics the disease in children under five years old to explore these immune responses and identify potential new treatments. The ultimate goal is to develop therapies that can improve recovery and reduce long-term respiratory health issues in children.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery from severe viral pneumonia in children, potentially improving their long-term respiratory health.
How similar studies have gone: While there is ongoing research into viral pneumonia, this specific approach focusing on regulatory T cells in young children is relatively novel and has not been extensively tested.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Prigge, Andrew — Lurie Children's Hospital of Chicago
- Study coordinator: Prigge, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.