Understanding how children with HIV stick to their medication regimen
Characterizing adherence and estimating per-protocol effects for pediatric dolutegravir use
This study looks at why kids with HIV sometimes have trouble sticking to their medication, focusing on things like how much help they get from their caregivers and how the medicine tastes, to find better ways to support them in taking their treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11126528 on NIH RePORTER |
What this research studies
This research investigates the challenges that children face in adhering to their antiretroviral therapy (ART) for HIV, focusing on factors such as caregiver involvement and the taste and tolerability of medications. By analyzing data from the ODYSSEY trial, which includes children aged 2 to 18, the study aims to identify patterns of nonadherence and estimate the effects of treatment failure over 96 weeks. The research employs modern statistical methods to better understand these issues and improve treatment strategies for pediatric patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 2 to 18 years living with HIV who are undergoing antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those outside the age range of 2 to 18 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved adherence to HIV treatment in children, ultimately reducing the risk of AIDS-related complications.
How similar studies have performed: Previous research has shown success in improving treatment adherence in pediatric populations through targeted interventions, making this approach both relevant and promising.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Li, Catherine Xin-Di — Univ of North Carolina Chapel Hill
- Study coordinator: Li, Catherine Xin-Di
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.