Understanding how childhood vaccines affect immune responses and respiratory diseases
Project 3: In vitro modeling to define mechanisms of childhood vaccine response, susceptibility to respiratory infectious disease and asthma
['FUNDING_OTHER'] · BOSTON CHILDREN'S HOSPITAL · NIH-11051849
This study is looking at how babies and young kids' immune systems react to vaccines and how that might affect their chances of getting respiratory infections and asthma, with the goal of finding better ways to protect them from these illnesses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11051849 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system of infants and young children responds to vaccines and its relationship with respiratory infections and asthma. Using advanced laboratory techniques, the study aims to model the immune responses of children to identify factors that influence vaccine effectiveness and susceptibility to diseases. By examining the signaling pathways involved in these immune responses, the research seeks to uncover mechanisms that could lead to improved vaccine strategies and treatments for respiratory conditions in young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years, particularly those with a history of low vaccine responsiveness or respiratory issues.
Not a fit: Patients outside the age range of 0-11 years or those without respiratory conditions or vaccine responsiveness issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better vaccines and treatments that enhance immune responses in children, reducing their risk of respiratory infections and asthma.
How similar studies have performed: Previous research has shown promise in using in vitro models to study immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVY, OFER — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: LEVY, OFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.