Understanding how childhood experiences affect adolescent depression

Leveraging population level data to inform prevention and treatment of adolescent depression following social adversities

NIH-funded research University of California, San Francisco · NIH-11166136

This study looks at how tough experiences in childhood can affect depression in teenagers, aiming to find out what helps some kids cope better than others, so we can improve support and treatment for those who need it most.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Francisco NIH-funded
Lab location1 site (San Francisco, United States)
Project IDNIH-11166136 on NIH RePORTER

What this research studies

This research investigates the link between adverse childhood experiences (ACEs) and adolescent depression, focusing on how different factors influence the risk and resilience to depression symptoms. By analyzing population-level data, the study aims to identify specific characteristics that contribute to varying outcomes in adolescents who have experienced ACEs. The goal is to enhance prevention and treatment strategies for those at risk, particularly in light of the mental health care shortages. The research will utilize advanced statistical methods to explore these complex interactions.

Who could benefit from this research

Good fit: Ideal candidates for this research include adolescents aged 12-20 who have experienced multiple adverse childhood events.

Not a fit: Patients who have not experienced any adverse childhood events may not receive benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for adolescents suffering from depression related to adverse childhood experiences.

How similar studies have performed: Previous research has shown that understanding the nuances of ACEs can significantly improve mental health interventions, indicating a promising avenue for this approach.

Where this research is happening

San Francisco, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.