Understanding how Chiari Type I Malformation affects brain development
Official title: Redefining Chiari Type I Malformation and its Impact on Brain Development
Funded at Washington University · NIH-10876257 · Data updated 2026-11-12
This study is looking at how Chiari Type I Malformation affects the brain and spinal cord in real life, rather than just through MRI scans, to better understand how it impacts your pain, neurological symptoms, and overall brain health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,508,020 |
| NIH project number | 5P01NS131131-02 |
| Project ID | NIH-10876257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Chiari Type I Malformation who experience neurological symptoms or cognitive challenges.
✕Less likely to help
Patients without a diagnosis of Chiari Type I Malformation or those who do not exhibit neurological symptoms may not benefit from this research.
What this research studies
This research investigates the complexities of Chiari Type I Malformation (CM), which is often oversimplified in clinical settings. It aims to redefine CM by examining the dynamic interactions between the cerebellum, brainstem, and spinal cord, rather than relying solely on static MRI images. The study will explore how these interactions affect patient experiences, including pain and neurological deficits, and their relationship to cognitive outcomes and associated conditions like syringomyelia. By utilizing advanced imaging and analysis techniques, the research seeks to provide a more comprehensive understanding of CM's impact on brain development.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients with Chiari Type I Malformation.
How similar studies have gone: Previous research has indicated that redefining complex conditions like Chiari Malformation can lead to significant advancements in understanding and treatment, suggesting potential success for this approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Lu, Chenyang — Washington University
- Study coordinator: Lu, Chenyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.