Understanding how chemotherapy affects brain blood vessels and cognition
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
This study is looking at how chemotherapy might affect thinking and memory in cancer survivors by examining changes in brain blood vessels, and it's aimed at helping those who have experienced 'chemobrain' to find ways to improve their cognitive health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10997435 on NIH RePORTER |
What this research studies
This research investigates the impact of chemotherapy on cognitive function in cancer survivors, specifically focusing on how chemotherapy-induced damage to blood vessels in the brain may lead to cognitive impairment, often referred to as 'chemobrain.' The study aims to understand the role of endothelial cell senescence, which occurs when these cells age prematurely due to chemotherapy exposure. Using a specialized mouse model, researchers will explore how this cellular aging affects blood flow and brain function, with the goal of identifying potential strategies to prevent or reverse cognitive decline in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are long-term cancer survivors who have experienced cognitive issues following chemotherapy.
Not a fit: Patients who have not undergone chemotherapy or those with pre-existing cognitive impairments unrelated to cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or mitigate cognitive impairment in cancer survivors.
How similar studies have performed: While the specific approach of targeting endothelial senescence in relation to chemotherapy-induced cognitive impairment is novel, there is growing evidence that addressing vascular health can improve cognitive outcomes in various populations.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Csiszar, Anna — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Csiszar, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.