Understanding how chemotherapy affects blood vessel function in cancer survivors
Official title: Mechanism of Chemotherapy Induced Microvascular Dysfunction in Cancer Survivors
Funded at Medical College of Wisconsin · NIH-11064060 · Data updated 2026-11-12
This study looks at how chemotherapy, especially a type called anthracyclines like doxorubicin, affects blood vessel health in breast cancer survivors, aiming to understand how these treatments might lead to heart problems later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $626,983 |
| NIH project number | 5R01HL173549-02 |
| Project ID | NIH-11064060 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer survivors who have undergone anthracycline-based chemotherapy.
✕Less likely to help
Patients who have not received chemotherapy or those with non-breast cancer diagnoses may not benefit from this research.
What this research studies
This research investigates the impact of chemotherapy, particularly anthracycline-based treatments like doxorubicin, on the function of blood vessels in breast cancer survivors. It focuses on how these treatments can lead to microvascular dysfunction and mitochondrial damage, which may contribute to cardiovascular issues. By examining the mechanisms behind these effects, the study aims to uncover the relationship between chemotherapy-induced damage and long-term health outcomes in patients. The research employs advanced techniques to analyze mitochondrial DNA damage and its role in vascular inflammation.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing cardiovascular health in cancer survivors, enhancing their overall quality of life.
How similar studies have gone: Previous research has indicated that chemotherapy can adversely affect cardiovascular health, but this specific mechanistic approach is relatively novel.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Beyer, Andreas M — Medical College of Wisconsin
- Study coordinator: Beyer, Andreas M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.