Understanding how chemicals disrupt ovarian development at the cellular level
Mechanisms of ovarian endocrine disruption at single-cell resolution
This study is looking at how certain chemicals that can disrupt hormones might affect the development of ovaries in fish, which could help us understand how these chemicals might impact reproductive health in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10890010 on NIH RePORTER |
What this research studies
This research investigates how exposure to endocrine disrupting chemicals (EDCs) during early ovarian development affects gene regulation in ovarian cells. Using the Japanese medaka fish as a model, the study aims to uncover the specific cellular responses to these chemicals and their long-term effects on reproductive health. By employing advanced analytical tools, researchers will analyze how these exposures alter the development of ovarian cells, which could lead to better understanding of reproductive diseases in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who may have been exposed to endocrine disrupting chemicals and are experiencing reproductive health issues.
Not a fit: Patients who are not affected by reproductive health issues or have not been exposed to relevant chemicals may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing reproductive health issues linked to chemical exposures.
How similar studies have performed: Previous research has shown success in using model organisms like medaka fish to study the effects of endocrine disruptors, indicating a promising approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Cossaboon, Jennifer Monique — University of California at Davis
- Study coordinator: Cossaboon, Jennifer Monique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.