Understanding how chemicals can cross barriers in male reproductive organs
Elucidating Chemical Features that Block or Facilitate Passage across the Blood-Testis and/or Blood-Epidydimal Barriers in Mice
This study is looking at how certain substances can move through barriers in male mice to help create better male contraceptives, making it easier to deliver medications to the reproductive system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10814176 on NIH RePORTER |
What this research studies
This research investigates the chemical properties that allow certain substances to pass through the blood-testis and blood-epididymal barriers in mice. By identifying these properties, the study aims to facilitate the development of new male contraceptives. The approach involves optimizing methods to measure how drugs distribute in mouse tissues and using advanced techniques like liquid chromatography mass spectrometry to analyze the distribution of various compounds. This could lead to breakthroughs in male contraception by improving drug delivery to the reproductive system.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be men interested in male contraceptive options or those involved in reproductive health studies.
Not a fit: Patients who are not male or those who do not have an interest in male contraception may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective male contraceptives that are safe and easy to use.
How similar studies have performed: Other research has shown promise in understanding drug delivery across similar biological barriers, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Feng — Baylor College of Medicine
- Study coordinator: Li, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.