Understanding how chemical modifications of RNA affect male fertility
Epitranscriptomic regulation of spermatogenesis and male fertility
['FUNDING_R01'] · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · NIH-10828422
This study is looking at how a special chemical change in messenger RNA, called m6A, affects the development of sperm and male fertility, which could help us understand more about men's reproductive health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER (nih funded) |
| Locations | 1 site (TORRANCE, UNITED STATES) |
| Trial ID | NIH-10828422 on ClinicalTrials.gov |
What this research studies
This research investigates the role of reversible chemical modifications of messenger RNA (mRNA) in the process of spermatogenesis, which is crucial for male fertility. The study focuses on a specific modification known as N6-methyladenosine (m6A) and how it regulates gene expression in developing male germ cells. By using biochemical analyses and knockout mouse models, the researchers aim to uncover the mechanisms by which m6A levels are controlled and their impact on sperm development. This could lead to new insights into male reproductive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing infertility issues related to sperm development.
Not a fit: Patients who are not experiencing fertility issues or have conditions unrelated to spermatogenesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for male infertility by targeting the molecular mechanisms involved in sperm development.
How similar studies have performed: Other research has shown promising results in understanding RNA modifications and their roles in various biological processes, suggesting that this approach could yield valuable insights.
Where this research is happening
TORRANCE, UNITED STATES
- LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER — TORRANCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAN, WEI — LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
- Study coordinator: YAN, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.