Understanding how chemical modifications in DNA affect cell behavior and cancer.
Mechanisms of epigenetic memory in human cells
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11128721
This study is looking at how changes in DNA can affect gene behavior in our cells, especially in relation to cancer, and it hopes to find new ways to treat the disease by understanding these changes better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11128721 on ClinicalTrials.gov |
What this research studies
This research investigates the role of DNA methylation, a key epigenetic modification, in determining how genes are expressed in human cells. By exploring the genetic pathways that influence DNA methylation, the study aims to uncover how abnormalities in these pathways contribute to diseases like cancer. The research employs advanced techniques such as genome-wide genetic screens and CRISPR technology to manipulate DNA methylation patterns, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about cancer cell behavior and the development of targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancer or those at high risk for developing cancer due to genetic factors.
Not a fit: Patients with non-cancerous conditions or those without any genetic predisposition to cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cancer treatment by targeting the mechanisms of DNA methylation.
How similar studies have performed: Other research has shown promising results in manipulating DNA methylation for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NUNEZ, JAMES KARLO — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: NUNEZ, JAMES KARLO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer immunotherapy, anticancer immunotherapy, cancer cell, cancer immunotherapy, cancer progenitor