Understanding how chemical injuries affect the eye
Official title: Unraveling the corneal and retinal mechanisms of chemical injury
Funded at University of Connecticut Sch of Med/dnt · NIH-10882069 · Data updated 2026-11-12
This study is looking at how certain chemicals can harm the eyes and cause vision problems, and it's aimed at helping people who might be affected by these injuries by finding better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $498,248 |
| NIH project number | 1R56EY035219-01 |
| Project ID | NIH-10882069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced chemical injuries to the eye or are at risk of such injuries.
✕Less likely to help
Patients with non-chemical related eye injuries or conditions may not benefit from this research.
What this research studies
This research investigates the effects of chemical agents, specifically sulfur mustard and nitrogen mustard, on the cornea and retina, which can lead to severe eye injuries and vision loss. The study aims to uncover the underlying mechanisms of these injuries, focusing on the role of specific enzymes and cellular responses in the eye. By using mouse models, researchers will explore how these chemicals trigger inflammatory responses and damage to ocular tissues, with the goal of developing effective treatments for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new medical treatments for chemical injuries to the eye, potentially preventing vision loss.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding the molecular mechanisms of eye injuries can lead to significant advancements in treatment.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Mohan, Royce — University of Connecticut Sch of Med/dnt
- Study coordinator: Mohan, Royce
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.