Understanding how chemical exposure affects airway cells in a lung disease.
Mechanisms of Basal Cell Dysfunction in Chemical-induced Bronchiolitis Obliterans
This study is looking at how certain chemicals, like those found in flavorings and e-cigarettes, can harm the cells in your lungs and contribute to bronchiolitis obliterans, a serious lung condition, to help find better treatments in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10911143 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind basal cell dysfunction in bronchiolitis obliterans (BO), a serious lung condition often linked to chemical exposure. The study focuses on how chemicals like diacetyl, commonly found in flavorings and e-cigarettes, can damage airway cells and lead to this disease. Using preclinical models, researchers will analyze the effects of these chemicals on airway cell function and repair processes. The goal is to uncover the biological pathways involved in BO to inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have been exposed to harmful chemicals and are experiencing symptoms related to bronchiolitis obliterans.
Not a fit: Patients with bronchiolitis obliterans not linked to chemical exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from bronchiolitis obliterans.
How similar studies have performed: While the specific mechanisms of chemical-induced bronchiolitis obliterans are not well-studied, related research on airway cell dysfunction has shown promising results in understanding lung diseases.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Mcgraw, Matthew Daniel — University of Rochester
- Study coordinator: Mcgraw, Matthew Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.