Understanding how chemical exposure affects airway cells in a lung disease.
Official title: Mechanisms of Basal Cell Dysfunction in Chemical-induced Bronchiolitis Obliterans
Funded at University of Rochester · NIH-10911143 · Data updated 2026-11-12
This study is looking at how certain chemicals, like those found in flavorings and e-cigarettes, can harm the cells in your lungs and contribute to bronchiolitis obliterans, a serious lung condition, to help find better treatments in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $234,038 |
| NIH project number | 5K08ES033290-03 |
| Project ID | NIH-10911143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have been exposed to harmful chemicals and are experiencing symptoms related to bronchiolitis obliterans.
✕Less likely to help
Patients with bronchiolitis obliterans not linked to chemical exposure may not benefit from this research.
What this research studies
This research investigates the mechanisms behind basal cell dysfunction in bronchiolitis obliterans (BO), a serious lung condition often linked to chemical exposure. The study focuses on how chemicals like diacetyl, commonly found in flavorings and e-cigarettes, can damage airway cells and lead to this disease. Using preclinical models, researchers will analyze the effects of these chemicals on airway cell function and repair processes. The goal is to uncover the biological pathways involved in BO to inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from bronchiolitis obliterans.
How similar studies have gone: While the specific mechanisms of chemical-induced bronchiolitis obliterans are not well-studied, related research on airway cell dysfunction has shown promising results in understanding lung diseases.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Mcgraw, Matthew Daniel — University of Rochester
- Study coordinator: Mcgraw, Matthew Daniel
Related research
Other NIH-funded projects on the same topics.
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Airway basal cell stress and environmentally caused bronchiolitis obliterans
Researchers are studying how certain inhaled chemicals may damage the airway’s foundational cells and lead to a serious lung disease called bronchiolitis obliterans.
-
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This work looks at how airway stem cells change after lung transplant to help people who develop obliterative bronchiolitis.
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Researchers are looking at how damage or repair of the lung's lymphatic vessels after transplant affects the chance of developing bronchiolitis obliterans in people who receive lung transplants.
-
How respiratory viruses affect long-term lung damage after donor stem cell transplant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.