Understanding how chaperone complexes affect tau protein in Alzheimer's disease
Official title: Tau proteostasis by chaperone-complexes in tauopathies including Alzheimer's disease
Funded at Weill Medical Coll of Cornell Univ · NIH-11088761 · Data updated 2026-11-12
This study is looking at how certain helper proteins can keep tau protein healthy and prevent it from clumping together, which is important for people with Alzheimer's and similar brain disorders, to find new ways to help treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $633,695 |
| NIH project number | 5R01AG083949-02 |
| Project ID | NIH-11088761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias characterized by tau pathology.
✕Less likely to help
Patients with tauopathies that do not involve tau protein aggregation or those with other unrelated neurodegenerative conditions may not benefit from this research.
What this research studies
This research investigates the role of chaperone complexes in maintaining the proper structure of tau protein, which is crucial in neurodegenerative disorders like Alzheimer's disease. The study aims to identify how these complexes influence tau aggregation and neurodegeneration by examining their effects in laboratory settings, including primary neurons and mouse models. By understanding the mechanisms behind tau protein misfolding and aggregation, the research seeks to uncover potential therapeutic targets for treating tauopathies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce tau aggregation, potentially slowing the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting protein aggregation in neurodegenerative diseases, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Sharma, Manu — Weill Medical Coll of Cornell Univ
- Study coordinator: Sharma, Manu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.