Understanding how changes in tissue stiffness affect colorectal cancer progression
Official title: On-Demand Modulation of Extracellular Matrix Mechanics for Studying RhoA Activation in Primary and Metastatic Colorectal Cancer
Funded at University of Washington · NIH-10889787 · Data updated 2026-11-12
This study is looking at how the stiffness of the surrounding tissue affects cancer cell behavior in colorectal cancer, using a special gel that can change its firmness with light, to help find better ways to treat the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $428,361 |
| NIH project number | 1R21CA283686-01A1 |
| Project ID | NIH-10889787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with advanced or metastatic disease.
✕Less likely to help
Patients with early-stage colorectal cancer or those without a diagnosis of colorectal cancer may not benefit from this research.
What this research studies
This research investigates the relationship between the stiffness of the extracellular matrix (ECM) and the activation of RhoA, a protein involved in cancer cell behavior, specifically in colorectal cancer (CRC). By developing a special hydrogel that can change stiffness in response to light, researchers aim to mimic the mechanical environment of both primary and metastatic tumors. This approach will help clarify how mechanical properties influence cancer cell growth and signaling, potentially leading to better treatment strategies. Patients may benefit from insights gained about how tumor stiffness affects cancer progression and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for colorectal cancer patients.
How similar studies have gone: Other research has shown promising results in understanding the role of mechanical properties in cancer progression, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Deforest, Cole a — University of Washington
- Study coordinator: Deforest, Cole a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.