Understanding how changes in the nuclear envelope can lead to liver cancer
Official title: Nuclear envelope and predisposition to hepatic neoplasia
Funded at Hackensack University Medical Center · NIH-10892309 · Data updated 2026-11-12
This study is looking at how chronic liver diseases, especially nonalcoholic steatohepatitis, can raise the chances of developing liver cancer, and it focuses on a protein called LAP1 to understand how changes in this protein might lead to cancer in people with liver issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $384,860 |
| NIH project number | 5R01CA283566-03 |
| Project ID | NIH-10892309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic liver diseases, especially those diagnosed with nonalcoholic steatohepatitis.
✕Less likely to help
Patients without chronic liver diseases or those who do not have a predisposition to liver cancer may not benefit from this research.
What this research studies
This research investigates the mechanisms by which chronic liver diseases, particularly nonalcoholic steatohepatitis, increase the risk of liver cancer. It focuses on a protein called lamina-associated polypeptide 1 (LAP1) that plays a crucial role in liver cell differentiation and metabolism. By studying how alterations in LAP1 expression affect liver cells, the research aims to uncover genetic changes that predispose individuals to hepatocellular carcinoma (HCC). This could lead to new insights into liver cancer development and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could provide new strategies for preventing or treating liver cancer in patients with chronic liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding the genetic mechanisms of liver cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Hackensack University Medical Center
Hackensack, United States Active
Researchers
- Principal investigator: Shin, Ji-Yeon — Hackensack University Medical Center
- Study coordinator: Shin, Ji-Yeon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.