Understanding how changes in the epigenome affect aging and senescence
Local and global epigenome regulation of senescence and aging
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11073860
This study is looking at how changes in our genes that don’t involve the DNA itself can affect aging and health, with the hope of finding ways to keep our cells healthier as we get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11073860 on ClinicalTrials.gov |
What this research studies
This research investigates how epigenetic mechanisms influence aging and age-related diseases by examining changes in gene expression without altering the DNA sequence. It focuses on the role of chromatin and epigenetic alterations in cellular aging, exploring how these changes can lead to tissue deterioration and impact overall health. The study aims to identify interventions that can enhance the maintenance of the epigenome, potentially leading to new therapeutic strategies for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing age-related health issues or those interested in interventions that may improve their aging process.
Not a fit: Patients who are not experiencing age-related changes or diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healthy aging and mitigate age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding epigenetic mechanisms in aging, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERGER, SHELLEY L — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BERGER, SHELLEY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder