Understanding how changes in the epigenome affect aging and senescence
Official title: Local and global epigenome regulation of senescence and aging
Funded at University of Pennsylvania · NIH-11073860 · Data updated 2026-11-12
This study is looking at how changes in our genes that don’t involve the DNA itself can affect aging and health, with the hope of finding ways to keep our cells healthier as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $506,404 |
| NIH project number | 1R01AG092045-01 |
| Project ID | NIH-11073860 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing age-related health issues or those interested in interventions that may improve their aging process.
✕Less likely to help
Patients who are not experiencing age-related changes or diseases may not benefit from this research.
What this research studies
This research investigates how epigenetic mechanisms influence aging and age-related diseases by examining changes in gene expression without altering the DNA sequence. It focuses on the role of chromatin and epigenetic alterations in cellular aging, exploring how these changes can lead to tissue deterioration and impact overall health. The study aims to identify interventions that can enhance the maintenance of the epigenome, potentially leading to new therapeutic strategies for age-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healthy aging and mitigate age-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding epigenetic mechanisms in aging, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Berger, Shelley L — University of Pennsylvania
- Study coordinator: Berger, Shelley L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.