Understanding how changes in RNA regulation affect prostate cancer progression
Official title: Elucidating alternative polyadenylation regulation during prostate cancer progression to castration-resistance
Funded at Duke University · NIH-11082532 · Data updated 2026-11-12
This study is looking at how changes in RNA might affect the way prostate cancer grows and becomes more serious, with the hope of finding new ways to improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $653,723 |
| NIH project number | 5R01CA290720-02 |
| Project ID | NIH-11082532 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with prostate cancer, particularly those experiencing progression to castration-resistant forms.
✕Less likely to help
Patients with early-stage prostate cancer that is not progressing may not benefit directly from this research.
What this research studies
This research investigates how alternative polyadenylation (APA), a process that modifies RNA transcripts, influences the progression of prostate cancer from treatable forms to more aggressive types. By analyzing RNA from clinical samples, the study aims to identify how changes in the length of specific RNA regions correlate with cancer severity. The researchers will use advanced bioinformatics and molecular biology techniques to uncover the mechanisms behind these changes and their implications for cancer treatment. This work could lead to new insights into how prostate cancer develops and progresses, potentially guiding future therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with advanced prostate cancer.
How similar studies have gone: Previous research has shown that understanding RNA regulation can significantly impact cancer treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Huang, Jiaoti — Duke University
- Study coordinator: Huang, Jiaoti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.