Understanding how changes in our genes affect health, especially in conditions like autism
Mechanisms and Phenotypic Consequences of Structural Genomic Variation
This research helps us learn how large-scale changes in our genetic material happen and what effects they have on living things, which is important for understanding conditions like Autistic Disorder.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11086684 on NIH RePORTER |
What this research studies
Our bodies are built on a genetic blueprint, and sometimes large sections of this blueprint can change, which we call structural genomic variation. We don't fully understand why these changes occur or how they impact health, but they are very important for conditions like autism. This project uses special tools in yeast, a simple model organism, to explore how chromosomes break and how cells try to prevent or fix this damage. By studying these basic processes, we hope to gain a deeper understanding of how genetic changes contribute to human conditions.
Who could benefit from this research
Good fit: Patients who might benefit from a deeper understanding of genetic changes related to conditions like autism are the focus of this foundational research.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into the genetic causes of conditions like Autistic Disorder, potentially leading to new ways to understand or address them in the future.
How similar studies have performed: The research team has already made significant progress in this field during previous funding periods, advancing our understanding of genomic changes.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Argueso, Juan Lucas — Colorado State University
- Study coordinator: Argueso, Juan Lucas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.