Understanding how changes in non-coding RNA regions affect gene function and protein production
High throughput functional annotation of the impact of human UTR sequence variation on gene function and protein output
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11049786
This study is looking at how certain genetic differences in parts of our genes that don’t code for proteins can affect how our bodies make proteins, which could help us understand diseases better and improve treatment options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11049786 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of genetic variations in the untranslated regions (UTRs) of mRNA on gene regulation and protein expression. By identifying and characterizing these variants, the study aims to develop a high-throughput method to quantify how each variant influences protein output across different cell types. Additionally, a computational model will be created to predict the effects of these variants, providing insights into their role in diseases. Patients may benefit from a better understanding of how genetic variations can affect their health and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders or those interested in understanding the genetic basis of their health conditions.
Not a fit: Patients with conditions unrelated to genetic variations in UTRs may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating genetic disorders linked to UTR variations.
How similar studies have performed: Other research has shown promise in understanding the role of UTR variations in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIRALDEZ, ANTONIO J — YALE UNIVERSITY
- Study coordinator: GIRALDEZ, ANTONIO J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.