Understanding how changes in non-coding RNA regions affect gene function and protein production
Official title: High throughput functional annotation of the impact of human UTR sequence variation on gene function and protein output
Funded at Yale University · NIH-11049786 · Data updated 2026-11-12
This study is looking at how certain genetic differences in parts of our genes that don’t code for proteins can affect how our bodies make proteins, which could help us understand diseases better and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $755,420 |
| NIH project number | 1R01HG013516-01A1 |
| Project ID | NIH-11049786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic disorders or those interested in understanding the genetic basis of their health conditions.
✕Less likely to help
Patients with conditions unrelated to genetic variations in UTRs may not receive any benefit from this research.
What this research studies
This research investigates the impact of genetic variations in the untranslated regions (UTRs) of mRNA on gene regulation and protein expression. By identifying and characterizing these variants, the study aims to develop a high-throughput method to quantify how each variant influences protein output across different cell types. Additionally, a computational model will be created to predict the effects of these variants, providing insights into their role in diseases. Patients may benefit from a better understanding of how genetic variations can affect their health and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating genetic disorders linked to UTR variations.
How similar studies have gone: Other research has shown promise in understanding the role of UTR variations in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Giraldez, Antonio J — Yale University
- Study coordinator: Giraldez, Antonio J
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.