Understanding how changes in molecular sequences affect their function and evolution
Characterizing the Effects of Sequence Variability in Molecular Function, Evolution and Design
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS DALLAS · NIH-11011946
This study is looking at how tiny changes in the building blocks of proteins can affect their function and help us understand how to create better vaccines and treatments for infections that are hard to treat.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS DALLAS (nih funded) |
| Locations | 1 site (RICHARDSON, UNITED STATES) |
| Trial ID | NIH-11011946 on ClinicalTrials.gov |
What this research studies
This research investigates how variations in biological sequences influence their functions and evolutionary advantages. By utilizing advanced computational techniques and models, the project aims to predict how changes in amino acid sequences can lead to new properties or detrimental effects in biomolecules. The research focuses on understanding the complex interactions that govern these changes, which could ultimately inform the design of new vaccines and treatments for antibiotic resistance. Patients may benefit from insights gained in this research that could lead to more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by antibiotic-resistant infections or those interested in the genetic basis of disease resistance.
Not a fit: Patients with non-infectious diseases or those not affected by antibiotic resistance may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines and treatments for antibiotic-resistant infections.
How similar studies have performed: Previous research has shown promise in using computational models to understand sequence variability and its implications for drug resistance, indicating that this approach has potential for success.
Where this research is happening
RICHARDSON, UNITED STATES
- UNIVERSITY OF TEXAS DALLAS — RICHARDSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORCOS, ALONSO FARUCK — UNIVERSITY OF TEXAS DALLAS
- Study coordinator: MORCOS, ALONSO FARUCK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.