Understanding how changes in mitochondrial DNA affect health
Understanding the regulation of mtDNA heteroplasmy and integrity
This work explores how changes in our cells' energy factories, called mitochondria, contribute to inherited diseases and common health problems like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11144963 on NIH RePORTER |
What this research studies
Our cells contain tiny powerhouses called mitochondria, which have their own small DNA. When this mitochondrial DNA (mtDNA) changes, it can lead to serious inherited conditions and is also linked to common diseases. We are using advanced sequencing technologies to better understand how these mtDNA changes happen and how their levels are controlled within cells. This helps us learn why some people develop these conditions and how the body tries to manage these changes. Our goal is to uncover the basic cellular processes that influence mtDNA health.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but it is relevant for individuals with maternally inherited diseases or those affected by cancers and other common pathologies linked to mitochondrial dysfunction.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how mitochondrial DNA mutations contribute to diseases, potentially opening doors for new ways to prevent or treat them.
How similar studies have performed: This project builds upon nearly 30 years of study and the team's own key contributions, utilizing new, ultra-high accuracy sequencing methods to address long-standing questions.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kennedy, Scott Robert — University of Washington
- Study coordinator: Kennedy, Scott Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.