Understanding how changes in immune cell behavior contribute to certain lymphomas
Dysregulated mechanoimmunology of epigenetics-driven lymphomas
['FUNDING_U01'] · GEORGIA INSTITUTE OF TECHNOLOGY · NIH-11075816
This study is looking into how certain changes in B cells can lead to types of lymphoma, like diffuse large B-cell lymphoma and follicular lymphoma, and it hopes to find new treatment options by understanding how these cells interact with the immune system, with the help of patients who might share their samples or information.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11075816 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), focusing on how germinal center B cells undergo changes that can lead to cancer. It examines the role of specific proteins and genetic mutations that disrupt normal B cell development and function, which may contribute to the growth of these lymphomas. By studying the interactions between B cells and other immune cells, the research aims to uncover potential targets for new treatments. Patients may be involved in providing samples or data that help elucidate these complex biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with diffuse large B-cell lymphoma or follicular lymphoma.
Not a fit: Patients with lymphomas not related to B cells or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lymphomas, improving outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of lymphomas, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA INSTITUTE OF TECHNOLOGY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGH, ANKUR — GEORGIA INSTITUTE OF TECHNOLOGY
- Study coordinator: SINGH, ANKUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.