Understanding how changes in immune cell behavior contribute to certain lymphomas
Official title: Dysregulated mechanoimmunology of epigenetics-driven lymphomas
Funded at Georgia Institute of Technology · NIH-11075816 · Data updated 2026-11-12
This study is looking into how certain changes in B cells can lead to types of lymphoma, like diffuse large B-cell lymphoma and follicular lymphoma, and it hopes to find new treatment options by understanding how these cells interact with the immune system, with the help of patients who might share their samples or information.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 9, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $518,073 |
| NIH project number | 5U01CA280984-03 |
| Project ID | NIH-11075816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals diagnosed with diffuse large B-cell lymphoma or follicular lymphoma.
✕Less likely to help
Patients with lymphomas not related to B cells or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), focusing on how germinal center B cells undergo changes that can lead to cancer. It examines the role of specific proteins and genetic mutations that disrupt normal B cell development and function, which may contribute to the growth of these lymphomas. By studying the interactions between B cells and other immune cells, the research aims to uncover potential targets for new treatments. Patients may be involved in providing samples or data that help elucidate these complex biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lymphomas, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of lymphomas, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Singh, Ankur — Georgia Institute of Technology
- Study coordinator: Singh, Ankur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.