Understanding how changes in genes affect kidney transplant health
Dissecting the role of dynamic epigenome prompting pathways leading to kidney allograft fibrosis
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10657610
This study is looking at why some kidney transplants don't work as well as they should, especially focusing on how scarring in the transplanted kidney happens, and it's for kidney transplant patients who want to help find ways to improve transplant success.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10657610 on ClinicalTrials.gov |
What this research studies
This research investigates the factors that lead to kidney transplant failure, particularly focusing on the development of fibrosis in kidney allografts. By studying a group of kidney transplant patients over time, the researchers are examining how genetic changes and inflammation contribute to the deterioration of kidney function. They are collecting and analyzing samples from both the transplanted kidneys and the patients' blood to identify early indicators of graft injury and potential pathways that could be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are at risk for chronic allograft dysfunction.
Not a fit: Patients who have not undergone kidney transplantation or those with acute kidney injury unrelated to transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant failure and enhancing long-term graft survival.
How similar studies have performed: Previous research has shown promising results in understanding kidney transplant outcomes through genetic and molecular analysis, indicating that this approach has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAS, VALERIA RAQUEL — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MAS, VALERIA RAQUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.