Understanding how changes in enzyme shape affect its function
Linking the conformational landscape to enzymatic function through functional site distant mutations
['FUNDING_R01'] · UNIVERSITY OF LOUISVILLE · NIH-11000315
This study is looking at how changes in the shape and movement of a specific enzyme, called human guanylate kinase, can affect how well it works, which could help us find new treatments for conditions like cancer and COVID-19.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-11000315 on ClinicalTrials.gov |
What this research studies
This research investigates how the shape and movement of enzymes, specifically human guanylate kinase (hGMPK), influence their ability to catalyze reactions. By examining mutations that occur far from the active site of the enzyme, the study aims to determine how these changes can affect the enzyme's performance without altering its overall structure. The researchers will use advanced techniques like nuclear magnetic resonance (NMR) spectroscopy to analyze these effects, which could lead to new insights into enzyme function and potential therapeutic applications for cancer and COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancer or those affected by SARS-CoV-2 who may benefit from new therapeutic strategies.
Not a fit: Patients with conditions unrelated to cancer or COVID-19 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective cancer treatments and therapies for COVID-19 by targeting enzyme functions.
How similar studies have performed: Other research has shown promise in understanding enzyme dynamics and their implications for drug development, suggesting that this approach could yield valuable insights.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SABO, THOMAS MICHAEL — UNIVERSITY OF LOUISVILLE
- Study coordinator: SABO, THOMAS MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, anti-cancer drug