Understanding how changes in DNA coding affect protein folding
Decoding the regulation of protein folding by synonymous codon usage
['FUNDING_OTHER'] · UNIVERSITY OF NOTRE DAME · NIH-10929942
This study is looking at how tiny changes in our genes, which don’t alter the proteins themselves, can still affect how those proteins fold and work in our cells, helping us understand more about genetic diseases related to protein problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NOTRE DAME (nih funded) |
| Locations | 1 site (NOTRE DAME, UNITED STATES) |
| Trial ID | NIH-10929942 on ClinicalTrials.gov |
What this research studies
This research investigates how synonymous mutations, which do not change the amino acid sequence of proteins, can still impact protein folding and function. By examining the effects of these mutations on protein homeostasis, the study aims to uncover the hidden complexities of genetic information that influence cellular mechanisms. The approach involves advanced techniques to analyze protein behavior in living cells, addressing a significant gap in our understanding of genetic variations and their consequences. This could lead to insights into various genetic diseases linked to protein misfolding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders that may involve protein misfolding or related cellular dysfunction.
Not a fit: Patients with conditions unrelated to protein folding or those without genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for treating genetic diseases caused by protein misfolding.
How similar studies have performed: While there have been limited studies on the effects of synonymous mutations on protein folding, this research aims to expand on these findings and explore uncharted territory.
Where this research is happening
NOTRE DAME, UNITED STATES
- UNIVERSITY OF NOTRE DAME — NOTRE DAME, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLARK, PATRICIA LOUISE — UNIVERSITY OF NOTRE DAME
- Study coordinator: CLARK, PATRICIA LOUISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.